“Alzheimer & Tauopathies” team belongs to the “Jean-Pierre Aubert Research Centre” and located in Lille, France.
Our team is interested in pathophysiological mechanisms leading to dementia and is composed of 16 permanent researchers: full time research scientists, professors and associate professors and clinicians. We also welcome postdoctoral fellows and MSc/PhD students. Our work focuses on tau, protein involved in the physiopathology of Alzheimer’s disease and related disorders referred to as Tauopathies, going from the gene to the clinic and from basic research to biomedical application.
“Alzheimer & Tauopathies” team is interested in molecular and pathophysiological mechanisms of tau pathophysiology. Our main contribution has been on the characterization of neurodegenerative disorders with dysfunction in tau metabolism (expression, splicing, etc.) and the development of experimental models. We also demonstrated that Tau proteins are biomarkers of these disorders and correlated to neuronal death.
Our current research should lead to new diagnostic and therapeutic strategies of Alzheimer’s disease and related disorders. To the level of the etiopathogenesis of Alzheimer’s disease, the understanding of the relationships between amyloid pathology and tau pathology is our main goal. Any molecular actors potentially involved in one of these pathways are evaluated in our experimental “humanized” models, as well as the related pharmacological aspects.
Team presentation, “Regards sur Alzheimer par le CNRS” :