Team 2 – Original Research

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Couverture du magazine Le Monde 17 janvier 2018
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DEVELOPMENT AND PLASTICITY OF THE NEUROENDOCRINE BRAIN TEAM

ORIGINAL RESEARCH

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

2018

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
Tata B, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Clasadonte J, Giacobini P.
Nat Med. 2018. doi: 10.1038/s41591-018-0035-5.

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus)
Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A
J Comp Neurol. 2018. 526(9):1419-1443

2017

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle
Clasadonte, J., E. Scemes, Z. Wang, D. Boison, and P.G. Haydon.
Neuron. 2017.  95:1365-1380.e5.

Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus
Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V
J Comp Neurol, 2017. 525:3177-3189

Tridimensional Visualization and Analysis of Early Human Development
Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A
Cell. 2017. 169:161-173 e112

2016

Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
Casoni F, Malone SA, Belle M, Luzzati F, Collier F, Allet C, Hrabovszky E, Rasika S, Prevot V, Chédotal V, Giacobini P
Development 2016 143: 3969-3981; doi: 10.1242/dev.139444

Leptin controls parasympathetic wiring of the pancreas during embryonic life
Croizier S, Prevot V, Bouret SG
Cell Reports, 15, 36-44, 2016

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits
Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, and Bouret
Hum Mol Genet. 25:3208-3215, 2016

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V
Nat Neurosci. 2016, doi:10.1038/nn.4298

Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Cimino I, Casoni F, Liu X, Messina A, Parkash J, Soazik P, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison A, Prevot V, Giacobini P
Nat Commun. 2016, 7:10055

2015

Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP, Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P
Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin
Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG.
Mol Metab. 2015, 4(1):15-24.

Neonatal ghrelin programs development of hypothalamic feeding circuits
Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, and Bouret SG.
J Clin Invest. 2015, 125(2):846-58.

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?
Mequinion M, Caron E, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas S, Prevot V, Chauveau C, Viltart O
Am J Physiol Endocrinol Metab. 2015, 1;308(3):E241-55

2014

Leptin dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction
Bellefontaine N, Chachlaki K, Parkash J, Vanaker C, Colledge W, d’Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V.
J Clin Invest 124:2550-2559, 2014.

Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V.
PLoS Biology 12(3):e1001808, 2014.

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.
Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175)

2013

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain
Langlet F, Mullier A, Bouret SG, Prévot V, Dehouck B.
J Comp Neurol. 2013 May 4 ; 521(15):3389-405 doi: 10.1002/cne.23355.

Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting
Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B.
Cell Metab. 2013 Apr 2;17(4):607-17. doi: 10.1016/j.cmet.2013.03.004.

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P.
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi:10.1073/pnas.1212137110.

2012

Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations.
Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, Giacobini P.
J Neurosci. 2012 Nov 21;32(47):16992-7002. doi: 10.1523/JNEUROSCI.3057-12.2012.

RIPping off GABA release in hypothalamic circuits causes obesity.
Bouret SG.
Cell Metab. 2012 Nov 7;16(5):557-8. doi: 10.1016/j.cmet.2012.10.014.

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
Hanchate NK, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, Leroy C, Baron S, Campagne C, Vanacker C, Collier F, Cruaud C, Meyer V, García-Piñero A, Dewailly D, Cortet-Rudelli C, Gersak K, Metz C, Chabrier G, Pugeat M, Young J, Hardelin JP, Prevot V, Dodé C.
PLoS Genet. 2012 Aug;8(8):e1002896. doi: 10.1371/journal.pgen.1002896.

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function.
Caron E, Ciofi P, Prevot V, Bouret SG.
J Neurosci. 2012 Aug 15;32(33):11486-94. doi: 10.1523/JNEUROSCI.6074-11.2012.

Embryonic birthdate of hypothalamic leptin-activated neurons in mice.
Ishii Y, Bouret SG.
Endocrinology. 2012 Aug;153(8):3657-67. doi: 10.1210/en.2012-1328.

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.
Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG.
Cell Metab. 2012 Feb 8;15(2):247-55. doi: 10.1016/j.cmet.2011.12.016.

Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits.
Bouret SG, Bates SH, Chen S, Myers MG Jr, Simerly RB.
J Neurosci. 2012 Jan 25;32(4):1244-52. doi: 10.1523/JNEUROSCI.2277-11.2012.

Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
Hanchate NK, Parkash J, Bellefontaine N, Mazur D, Colledge WH, d’Anglemont de Tassigny X, Prevot V.
J Neurosci. 2012 Jan 18;32(3):932-45. doi: 10.1523/JNEUROSCI.4765-11.2012.

MRI atlas of the human hypothalamus.
Baroncini M, Jissendi P, Balland E, Besson P, Pruvo JP, Francke JP, Dewailly D, Blond S, Prevot V.
Neuroimage. 2012 Jan 2;59(1):168-80. doi: 10.1016/j.neuroimage.2011.07.013.

2011

Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.
Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P.
Hum Mol Genet. 2011 Dec 15;20(24):4759-74. doi: 10.1093/hmg/ddr403.

Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V.
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16104-9. doi: 10.1073/pnas.1107533108.

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring.
Steculorum SM, Bouret SG.
Endocrinology. 2011 Nov;152(11):4171-9. doi: 10.1210/en.2011-1279.

2010

Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle.
Parkash J, d’Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V, Prevot V.
Endocrinology. 2010 Jun;151(6):2723-35. doi: 10.1210/en.2010-0007.

Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence.
De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V.
Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
Mullier A, Bouret SG, Prevot V, Dehouck B.
J Comp Neurol. 2010 Apr 1;518(7):943-62. doi: 10.1002/cne.22273.

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain.
Caron E, Sachot C, Prevot V, Bouret SG
J Comp Neurol. 2010 Feb 15;518(4):459-76. doi: 10.1002/cne.22219.

Sex steroid hormones-related structural plasticity in the human hypothalamus.
Baroncini M, Jissendi P, Catteau-Jonard S, Dewailly D, Pruvo JP, Francke JP, Prevot V.
Neuroimage. 2010 Apr 1;50(2):428-33. doi: 10.1016/j.neuroimage.2009.11.074.