Team 2 – Our Team

NEWS

Couverture du magazine Le Monde 17 janvier 2018

DEVELOPMENT AND PLASTICITY OF THE NEUROENDOCRINE BRAIN TEAM

OUR TEAM

PRINCIPLE INVESTIGATORS

Vincent Prévot

LAB DIRECTOR
Dr. Vincent Prévot, Ph.D

Lead researcher and head of the laboratory.

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Paolo Giacobini

Dr. Paolo Giacobini, Ph.D
Principal Investigator & Group Leader.

Expert on developmental neuroscience and neuronal migration.

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Sébastien Bouret

Dr. Sébastien Bouret, Ph.D
Principal Researcher & Group Leader.

Jointly based between the University of Southern California (USC) and our Laboratory, Sebastien’s work is focused on changes to hypothalamic rewiring that impacts the control of metabolic feedback loops and targeting methods to treat obesity disorders.

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Ariane Sharif

Dr. Ariane Sharif, Ph.D
Principal Researcher & Lecturer (University of Lille 2).

Ariane’s Research focuses on the importance of glial cells in regulating neuroendocrine processes and targeting therapeutic interventions for glioblastomas.

Bénédicte Dehouck

Dr. Bénédicte Dehouck, Ph.D
Principal Researcher & Lecturer (University of Artois).

Study of blood-brain interfaces in contributing to the delivery of blood-borne molecules to their neuronal targets.

Marc Baroncini

Dr. Marc Baroncini, M.D, Ph.D
Principal Researcher & Neurosurgeon (CHRU).

Marc is a renowned neurosurgeon at Lille’s Regional Hospital Centre (CHRU) and his research focuses on hypothalamic control of metabolism with regards to eating disorders.

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CLINICAL PARTNERS

Didier Dewailly

Professor Didier Dewailly, M.D
Head of Gynaecology, Endocrine and Reproductive Medicine, Professor & Practitioner.

Jeanne de Flandre Hospital

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure.

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Sophie Catteau-Jonard

Dr. Sophie Catteau-Jonard, M.D, Ph.D
Assistant Professor & Practitioner, Jeanne de Flandre Hospital.
Jeanne de Flandre Hospital

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure.

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Professor Claude-Alain Maurage, M.D
Anatomopathologist, Pathology Dept.

CHRU of Lille.

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Professor Serge Blond, M.D
Professor & Neurosurgeon.
Roger Salengro Hospital

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TECHNICIANS

Danielle Mazur

Danielle Mazur

Responsibilities: Maintenance and utilization of the cryostats, microtomes etc. Perfusion Room.
Key Techniques: Immunohistochemistry, Immunofluorescence.
Publications :
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.

Anne Loyens

Anne Loyens
Assistant Engineer.

Responsibilities: Electron Microscope. Cell Culture Room.
Key Techniques: Immunohistochemistry, Immunofluorescence, Cell Culture, Electron Microscopy, ISH.
Publications :
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V. Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence. Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.

ENGINEERS

Cécile Allet

Dr. Cécile Allet, Ph.D
Research Engineer
Supervisor: Dr. Paolo Giacobini.

Formation : Thèse de doctorat de l’Université de Lille 2 “Gliogenèse dans lhypothalamus au cours du développement post-natal : implication dans le contrôle de la maturation sexuelle femelle”.
Responsabilités :
Responsable du plateau de microscopie phonique du Centre JPArc. Responsable du parc de balances du Centre JPArc.
Formation supplémentaire : Microscopie phonique, Microscopie électronique, Microscopie à feuille de lumière, Immunohistochimie, hybridation in situ, histologie du cerveau rongeur et humain, Expérimentation animale.
Publications :
Casoni et al, Development. 2016; 143(21):3969-3981
Delavalle et al, Exp Cell Res. 2011; 317(18):2683-94
Lee-Chang et al, Immunol lett. 2011; 135(1-2):108-17
Prevot et al, Front Neuroendocrinol. 2010; 31(3):241-58
Venna et al, Psychoneuroendocrinology. 2009; 34(2):199-211
Sharif et al, Glia. 2009; 57(4):362-79
Baroncini et al, J Neuroendocrinol. 2007; 19(9):691-702
Sharif et al, Oncogene. 2007; 26(19):2695-706
Sharif et al, Oncogene. 2006: 25(29):4076-85.

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Émilie Caron

Dr. Émilie Caron, Ph.D
Research Engineer.
Head of the core for murine metabolic phenotyping.

Education: Ph.D University of Lille 2 “Leptin & hypothalamic regulation of reproductive function in mice” 2006. M.Sc. Neuroscience, University of Lille 2, France, 2003.
Responsibilities: Maintenance and Use of Metabolic Cages.
Publications :
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175).
Physical activity: benefit or weakness in metabolic adaptations in a mouse model of  chronic food restriction? Méquinion M,  Caron E, Zgheib S, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas S, Prévot V, Chauveau C, Viltart O. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E241-55.

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Sarah Gallet

Sarah Gallet
Study Engineer

Supervisor: Dr. Vincent Prevot.
Impact of melatonin hormone on the blood-brain-barrier at the level of the median eminence.
Education: M.Sc. Biology Biotechnology, University of Lille, 2011.
Responsibilities: Responsible for L2 Cell Culture. Registrar of GMO database.
Additional Training: Animal Experimentation Level I (IV, IP, intracardiac perfusion).
Publications :
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.

POST DOCS

Maria Manfredi-Lozano

Dr. Maria Manfredi Lozano, Ph.D
Supervisor: Dr. Vincent Prévot.

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Supported by the Marie Sktodowska-Curie action – Research Fellowship Programme

Jérôme Clasadonte

Dr. Jérôme Clasadonte, Ph.D
Supervisor: Dr. Vincent Prévot.

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Supported by the Marie Sktodowska-Curie action – Research Fellowship Programme

Monica Imbernon

Dr. Monica Imbernon, Ph.D
Supervisor: Dr. Vincent Prévot.

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Supported by the Marie Sktodowska-Curie action – Research Fellowship Programme

Sonal Shruti

Dr. Sonal Shruti, Ph.D
Supervisor: Dr. Vincent Prévot.

Supported by Métropole Européenne de Lille grant

Daniela Fernandois

Dr. Daniela Fernandois, Ph.D
Supervisor: Dr. Vincent Prévot.

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Konstantina Chachlaki

Dr. Konstantina Chachlaki, Ph.D
Supervisors: Dr. Vincent Prévot and Pr. John Garthwaite (UCL).

Education: Ph.D in Neuroscience: University of Lille 2. 2016M.Sc. Brain and Mind Sciences: University College London (UCL), University Pierre and Marie Curie (UPMC), École Normale Supérieure (ENS) 2010-2012. Molecular Biology Diploma: University of Crete, 2010-2006.
Publications :
Chachlaki et al., Nat Rev Endocrin,10.1038/nrendo.2017.69. 2017.
Chachlaki et al., J Comp Neurol, 10.1002/cne.24257. 2017.
Chachlaki & Prevot, PNAS, 1600717113, 2016.
Messina A et al., Nature Neuroscience 19, 835–844 (2016).
Alterio J et al., Traffic 16(9) 2015.
Bellefontaine N et al., J Clin Invest 124:2550-2559, 2014.
Bhargava Y et al., Front Mol Neurosci.6:26, 2013.

Samuel Malone

Dr. Samuel Malone, Ph.D
Supervisor: Dr. Paolo Giacobini.
Anti-Müllerian hormone and the development of the gonadotropin-releasing hormone (GnRH) neuronal system.

Education: M.Sc. Neuroscience, University of Lille 2, France, 2014. B.Sc. Hons. Anatomical Science, University of Bristol, United Kingdom, 2012.
Publications :
Chachlaki et al., J Comp Neurol, 10.1002/cne.24257. 2017.
Belle et al., Cell. 2017, (3)008.
Casoni & Malone et al., Development. 2016, 1;143(21):3969-3981.
Parkash et al., Nat Commun. 2015, 6:6385.

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Giuliana Pellegrino

Dr. Giuliana Pellegrino, Ph.D
Supervisor: Dr. Ariane Sharif.
Cell neogenesis in the hypothalamus: a new mechanism of control of reproductive function.

Education: M.Sc. Cellular and Molecular Biology, University of Turin, Italy 2012-14. B.Sc. Biological Science, University of Catania, Italy, 2008-11.

Sara Trova

Dr. Sara Trova, Ph.D
Supervisor: Dr. Paolo Giacobini.

Education: Ph.D. Neuroscience, University of Turin, Italy 2014-18. M.Sc. Cellular and Molecular Biology, University of Turin, Italy 2012-14.

DOCTORAL STUDENTS

Manon Duquenne

Manon Duquenne
Supervisor: Dr. Vincent Prévot.
The importance of calcium dependent exocytosis in the tanycyte mediated transport of leptin.

Education: Master 1 Research Physiology et Physiopathology of human diseases, Lille 1 and Lille 2 University, France.

Vincent Florent

Dr Vincent Florent, MD
Supervisor: Dr. Marc Baroncini.
Hypothalamic communication with the periphery research in humans: impact on the cerebral metabolic activity and the control of energy homeostasis.

Education: M.Sc Paris VII Diderot: Nutrition, metabolism, signaling. France. Medic`l doctor and hospital practitioner, Arras General Hospital. Graduate of complementary specialized studies in nutrition. University degree: Human nutrition & public health. University degree: Clinical research.

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Valérie Leysen

Valerie Leysen
Supervisor: Dr. Vincent Prévot.

Education: Biomedical sciences, University of Antwerp, Belgium, 2014. M.Sc. Neuroscience, University of Antwerp, Belgium, 2016.

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Nour El Houda Mimouni

Nour El Houda Mimouni
Supervisor: Dr. Paolo Giacobini.

Education: Master Reproduction and development, University of Paris VII.

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Anne-Laure Barbotin

Dr. Anne-Laure Barbotin, M.D
Supervisors: Pr. Sophie Catteau-Jonard and Dr. Valerie Mitchell.
Neurostructural hypothalamic plasticity in polycystic ovary syndrome.

Education: Master 2, Paris V University, France.

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Mégane Piet

Megane Piet
Supervisor: Dr. Bénédicte Dehouck.
Involvement of estrogen in the regulation of access of metabolic signals to their cerebral targets.

Education: Master 2, University of Rouen, France.

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Marion Martin

Marion Martin
Supervisor: Dr. Ariane Sharif.

Education: Master 2,  France.

Maeliss Peigné

Dr. Maëliss Peigné, M.D
Supervisor: Pr. Sophie Catteau-Jonard.

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