“Welcome to Mucins, Epithelial Differentiation and Carcinogenesis team.”
MUCINS, EPITHELIAL DIFFERENTIATION AND CARCINOGENESIS TEAM
STAFF
RESEARCHERS
Dr Isabelle VAN SEUNINGEN
Researcher, DR1 CNRS, PhD
Research: Role of MUC4 mucin in pancreatic carcinogenesis. Structure-function study of the MUC4-ErbB2 complex. Role of MUC2 in host-bacteria relationship and intestinal barrier.
Keywords: Mucins, MUC2, MUC4, MUC5B, epithelial pathophysiology, cancer, inflammation, chemoresistance, pancreas, gastro-intestinal tract, cell differentiation, regulation of gene expression, transcription, cell signaling, epigenetics, structure-function.
Dr Nicolas JONCKHEERE
Researcher, CRCN Inserm, PhD
Research: Role of MUC4 membrane-bound mucin in pancreatic carcinogenesis and chemoresistance.
Keywords: MUC4, pancreatic adenocarcinoma, transgenic mouse models, neoplastic lesions PanIN, chemoresistance.
Dr Bernadette NEVE
Researcher, CRCN Inserm, PhD
Research: Impact of long non-coding RNAs on cellular behaviour and properties of cancer cells.
Keywords: Long non-coding RNAs (lncRNAs), colorectal cancer, epigenetic plasticity, CRISPR/Cas9 genome editing.
Dr Audrey VINCENT
Researcher, CRCN Inserm, PhD
Research: Role of epigenetic mechanisms in cancer cell stemness and plasticity.
Keywords: Epigenetics, DNA methylation, Histone code, cancer stem cells, colon cancers, pancreatic adenocarcinomas.
Dr Michaël PERRAIS
Associate Professor, PhD
Research: Roles of MUC1 in kidney.
Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.
Teaching: Biochemistry, molecular and cellular biology (Medicine School and Master 1 degree).
Pr Sébastien AUBERT
Anatomopathologist, MD PhD
Research: Roles of MUC1 in kidney pathophysiology.
Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.
Pr Marie-Pierre BUISINE
Biologist, PharmD PhD
Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology.
Pr Mohammed HEBBAR
Oncologist, MD PhD
Research: N/C.
Keywords: N/C.
Pr Emmanuelle LETEURTRE
Anatomopathologist, MD PhD
Research/teaching: Cytology and pathology in the fields of gastrointestinal, pancreatic and liver diseases. Diagnostic and prognostic markers. Immunohistochemistry.
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Pr Guillaume PIESSEN
Digestive surgeon, MD PhD
Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology. Coordinator of FREGAT database.
Pr Pascal PIGNY
Biologist, PharmD PhD
Research: Impact of galectin-3 on mucin and non mucin mRNAs half-life and trafficking
Keywords: galectin, mucin, mRNA, cancer cells.
Pr Stéphanie TRUANT
Digestive surgeon, MD PhD
Research: N/C.
Keywords: N/C.
Teaching: N/C.
Dr Anne-Frédérique DESSEIN
Biologist, PharmD PhD
Research: N/C.
Keywords: N/C.
Teaching: N/C.
Dr Viviane GNEMMI
Anatomopathologist, MD PhD
Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.
Dr Guillemette HUET
Biologist, PharmD PhD
Research: N/C.
Keywords: N/C.
Teaching: N/C.
Dr Julie LECLERC
Biologist, PharmD PhD
Research: N/C.
Keywords: N/C.
Dr Florence RENAUD
Anatomopathologist, MD PhD
Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology.
https://www.fregat-database.org/
Dr Lucie COPPIN
Biologist, PharmD PhD
Research: Post-transcriptional regulation of mucin expression by galectin-3.
Keywords: mucins, galectin-3, mRNA metabolism, RNA Binding Protein, pancreatic adenocarcinoma.
Dr Deniz PEKIN
Postdoctoral fellow, PhD
Dr. Deniz Pekin obtained a PhD in Chemical Biology from the University of Strasbourg. Her work, under the supervision of Dr. Valérie Taly, resulted in the development of a novel molecular diagnostics system: the droplet digital PCR (ddPCR), which was later commercialized by the Startup Raindance Technologies. She did a post-doc in groups directed by Prof. Jean-Christophe Baret at the Max-Planck Institute for Dynamics and Self-organization (Goettingen, Germany) and then in the Soft Microsystems at the Centre de Recherche Paul-Pascal in Bordeaux (France), where she worked on synthetic biology and complex systems. Her work resulted in 15 journal publications, 1 pending patent and 7 conference presentations.
Research: Despite the recent advances in the fields of surgery, the efficiency of treatment regiments and chemotherapy and radiotherapy, some forms of cancer show an inherent or acquired resistance against treatments which induces a therapeutically failure. These phenomena are even the more marked in the case of oesogastric cancers especially in the case of gastric poorly cohesive carcinoma which has an increasing incidence in the western world and in our region Hauts-de-France. The rich abundance of stroma is a typical characteristic of gastric poorly cohesive carcinomas. The link between the chemo-resistance and the abundance of stroma is nonetheless unknown. This project aims at creating microfluidic 4D models of tumors on-chip using droplet-based microfluidics and tissue engineering. These models should allow us to better understand the cellular mechanisms involved in the drug resistance by isolating the components of the stroma involved in this process and identify or even discover novel cancer biomarkers allowing to observe, predict and eliminate this resistance. This technology should also allow us to develop a new functional clinical test for the routine use in personalized medicine (drug resistance, choice of treatment regimen).
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, digital PCR, synthetic biology.
Dr Clarisse EVENO
Surgeon, MD PhD
Research:
Keywords:
ENGINEERS / TECHNICIANS
Mr Mouloud SOUIDI
University of Lille Engineer
In charge of L2 and bacteriology laboratories, autoclave, GMO and cell lines collections.
Skills: molecular biology, genome editing, epigenetics, Crispr/cas9, cellular biology.
Mrs Belinda DUCHÊNE
Inserm Research technician
Prevention assistant, in charge of chemical reagents.
Skills: immunochemistry, protein biochemistry, animal experimentation, genotyping, molecular biology.
Mrs Marie-Paule DUCOUROUBLE
Inserm Research technician
Prevention assistant, lab manager (ordering, stocks, new staff, good laboratory practice).
Skills: protein biochemistry.
Mrs Brigitte HÉMON-REMY
Inserm Research technician
In charge of L2 laboratories and autoclave.
Skills: cell culture, animal models, molecular and cellular biology, immunochemistry, microscopy.
Dr Romain VASSEUR
ANR fellow, Research Engineer
Skills: animal experimentation, protein biochemistry, molecular and cellular biology, 2D cell culture, immunochemistry.
Mrs Marie VANDEPEUTTE
Inserm fellow, Engineer
Skills: animal models, genotyping, 2D and 3D cell culture, organoids, microscopy, molecular biology.
STUDENTS
Nihad BOUKROUT
(Y1, PhD student)
Roles of miR-210 in pancreatic carcinogenesis and chemoresistance.
Frédérick DE MIOLLIS
(Y1, PhD student)
Development of a 3D in vitro microfluidic culture system to study tumor-stroma interactions and drug resistance of pancreatic adenocarcinoma.
Thomas SWIERCZEWSKI
(Y1, PhD student)
MUC1 : an actor in chemoresistance and a new therapeutic target in renal cell carcinoma.
Marjolaine BAUZONE
(Y2, PhD student)
Relationship between YAP and retinoic acid receptor (RAR) mediated pathways in cancer stem cell phenotype and cell reprogramming.
Dr Jean-Baptiste GIBIER
(Y2, PhD student)
Immunomodulatory role of MUC1 in renal diseases.
Dr François CORFIOTTI
(Y4, PhD student)
Molecular mechanisms associated with acquired chemoresistance in pancreatic adenocarcinoma.
Mehdi EL AMRANI
(Y4, PhD student)
Gemcitabine-induced EMT-like changes sustain chemoresistance of pancreatic cancer cells.