Team 5 – Staff

“Welcome to Mucins, Epithelial Differentiation and Carcinogenesis team.”

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équipe mucines, différenciation cancérogenèse épithéliales

MUCINS, EPITHELIAL DIFFERENTIATION AND CARCINOGENESIS TEAM

STAFF

RESEARCHERS

Isabelle Van Seuningen

Dr Isabelle VAN SEUNINGEN
Researcher, DR1 CNRS, PhD

Research: Role of MUC4 mucin in pancreatic carcinogenesis. Structure-function study of the MUC4-ErbB2 complex. Role of MUC2 in host-bacteria relationship and intestinal barrier.
Keywords: Mucins, MUC2, MUC4, MUC5B, epithelial pathophysiology, cancer, inflammation, chemoresistance, pancreas, gastro-intestinal tract, cell differentiation, regulation of gene expression, transcription, cell signaling, epigenetics, structure-function.

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Nicolas Jonckheere

Dr Nicolas JONCKHEERE
Researcher, CRCN Inserm, PhD

Research: Role of MUC4 membrane-bound mucin in pancreatic carcinogenesis and chemoresistance.
Keywords: MUC4, pancreatic adenocarcinoma, transgenic mouse models, neoplastic lesions PanIN, chemoresistance.

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Bernadette Neve

Dr Bernadette NEVE
Researcher, CRCN Inserm, PhD

Research: Impact of long non-coding RNAs on cellular behaviour and properties of cancer cells.
Keywords: Long non-coding RNAs (lncRNAs), colorectal cancer, epigenetic plasticity, CRISPR/Cas9 genome editing.

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Audrey Vincent

Dr Audrey VINCENT
Researcher, CRCN Inserm, PhD

Research: Role of epigenetic mechanisms in cancer cell stemness and plasticity.
Keywords: Epigenetics, DNA methylation, Histone code, cancer stem cells, colon cancers, pancreatic adenocarcinomas.

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Dr Michaël PERRAIS
Associate Professor, PhD

Research: Roles of MUC1 in kidney.
Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.
Teaching: Biochemistry, molecular and cellular biology (Medicine School and Master 1 degree).

Pr Sébastien AUBERT
Anatomopathologist, MD PhD

Research: Roles of MUC1 in kidney pathophysiology.
Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.

Pr Marie-Pierre BUISINE
Biologist, PharmD PhD

Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology.

https://www.fregat-database.org/

Pr Mohammed HEBBAR
Oncologist, MD PhD

Research: N/C.
Keywords: N/C.

Emmanuelle Leteurtre

Pr Emmanuelle LETEURTRE
Anatomopathologist, MD PhD

Research/teaching: Cytology and pathology in the fields of gastrointestinal, pancreatic and liver diseases. Diagnostic and prognostic markers. Immunohistochemistry.

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Guillaume Piessen

Pr Guillaume PIESSEN
Digestive surgeon, MD PhD

Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology. Coordinator of FREGAT database.

www.fregat-database.org

Pascal Pigny

Pr Pascal PIGNY
Biologist, PharmD PhD

Research: Impact of galectin-3 on mucin and non mucin mRNAs half-life and trafficking
Keywords: galectin, mucin, mRNA, cancer cells.

Pr Stéphanie TRUANT
Digestive surgeon, MD PhD

Research: N/C.
Keywords: N/C.
Teaching: N/C.

Dr Anne-Frédérique DESSEIN
Biologist, PharmD PhD

Research: N/C.
Keywords: N/C.
Teaching: N/C.

Viviane Gnemmi

Dr Viviane GNEMMI
Anatomopathologist, MD PhD

Keywords: Cancer, fibrosis, inflammation, chemoresistance, signaling pathway.

Dr Guillemette HUET
Biologist, PharmD PhD

Research: N/C.
Keywords: N/C.
Teaching: N/C.

Dr Julie LECLERC
Biologist, PharmD PhD

Research: N/C.
Keywords: N/C.

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Florence Renaud

Dr Florence RENAUD
Anatomopathologist, MD PhD

Research: Prevention and management of tumor recurrence in esogastric cancers.
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, recurrence, digestive oncology, molecular oncology.

https://www.fregat-database.org/

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Lucie Coppin

Dr Lucie COPPIN
Biologist, PharmD PhD

Research: Post-transcriptional regulation of mucin expression by galectin-3.
Keywords: mucins, galectin-3, mRNA metabolism, RNA Binding Protein, pancreatic adenocarcinoma.

Deniz-Pekin

Dr Deniz PEKIN
Postdoctoral fellow, PhD

Dr. Deniz Pekin obtained a PhD in Chemical Biology from the University of Strasbourg. Her work, under the supervision of Dr. Valérie Taly, resulted in the development of a novel molecular diagnostics system: the droplet digital PCR (ddPCR), which was later commercialized by the Startup Raindance Technologies. She did a post-doc in groups directed by Prof. Jean-Christophe Baret at the Max-Planck Institute for Dynamics and Self-organization (Goettingen, Germany) and then in the Soft Microsystems at the Centre de Recherche Paul-Pascal in Bordeaux (France), where she worked on synthetic biology and complex systems. Her work resulted in 15 journal publications, 1 pending patent and 7 conference presentations.

Research: Despite the recent advances in the fields of surgery, the efficiency of treatment regiments and chemotherapy and radiotherapy, some forms of cancer show an inherent or acquired resistance against treatments which induces a therapeutically failure. These phenomena are even the more marked in the case of oesogastric cancers especially in the case of gastric poorly cohesive carcinoma which has an increasing incidence in the western world and in our region Hauts-de-France. The rich abundance of stroma is a typical characteristic of gastric poorly cohesive carcinomas. The link between the chemo-resistance and the abundance of stroma is nonetheless unknown. This project aims at creating microfluidic 4D models of tumors on-chip using droplet-based microfluidics and tissue engineering. These models should allow us to better understand the cellular mechanisms involved in the drug resistance by isolating the components of the stroma involved in this process and identify or even discover novel cancer biomarkers allowing to observe, predict and eliminate this resistance. This technology should also allow us to develop a new functional clinical test for the routine use in personalized medicine (drug resistance, choice of treatment regimen).
Keywords: esogastric adenocarcinoma, translational research, chemoresistance, digital PCR, synthetic biology.

Dr Clarisse EVENO
Surgeon, MD PhD

Research:
Keywords:

ENGINEERS / TECHNICIANS

Mouloud Souidi

Mr Mouloud SOUIDI
University of Lille Engineer

In charge of L2 and bacteriology laboratories, autoclave, GMO and cell lines collections.
Skills: molecular biology, genome editing, epigenetics, Crispr/cas9, cellular biology.

Belinda Duchêne

Mrs Belinda DUCHÊNE
Inserm Research technician

Prevention assistant, in charge of chemical reagents.
Skills: immunochemistry, protein biochemistry, animal experimentation, genotyping, molecular biology.

Marie-Paule Ducourouble

Mrs Marie-Paule DUCOUROUBLE
Inserm Research technician

Prevention assistant, lab manager (ordering, stocks, new staff, good laboratory practice).
Skills: protein biochemistry.

Brigitte Hémon

Mrs Brigitte HÉMON-REMY
Inserm Research technician

In charge of L2 laboratories and autoclave.
Skills: cell culture, animal models, molecular and cellular biology, immunochemistry, microscopy.

Romain Vasseur

Dr Romain VASSEUR
ANR fellow, Research Engineer

Skills: animal experimentation, protein biochemistry, molecular and cellular biology, 2D cell culture, immunochemistry.

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Mrs Marie VANDEPEUTTE
Inserm fellow, Engineer

Skills: animal models, genotyping, 2D and 3D cell culture, organoids, microscopy, molecular biology.

STUDENTS

Nihad Boukrout

Nihad BOUKROUT
(Y1, PhD student)

Roles of miR-210 in pancreatic carcinogenesis and chemoresistance.

Frédérick de Miollis

Frédérick DE MIOLLIS
(Y1, PhD student)

Development of a 3D in vitro microfluidic culture system to study tumor-stroma interactions and drug resistance of pancreatic adenocarcinoma.

Thomas Swierczewski

Thomas SWIERCZEWSKI
(Y1, PhD student)

MUC1 : an actor in chemoresistance and a new therapeutic target in renal cell carcinoma.

Marjolaine Bauzone

Marjolaine BAUZONE
(Y2, PhD student)

Relationship between YAP and retinoic acid receptor (RAR) mediated pathways in cancer stem cell phenotype and cell reprogramming.

Jean-Baptiste Gibier

Dr Jean-Baptiste GIBIER
(Y2, PhD student)

Immunomodulatory role of MUC1 in renal diseases.

Dr François CORFIOTTI
(Y4, PhD student)

Molecular mechanisms associated with acquired chemoresistance in pancreatic adenocarcinoma.

Mehdi EL AMRANI
(Y4, PhD student)

Gemcitabine-induced EMT-like changes sustain chemoresistance of pancreatic cancer cells.