Thesis defend

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Thesis defend

CUVELIER Elodie
MCCH Team, under the supervision of BELARBI Karim

PhD defense : 28/02/2019

Metabolic phenotype and pharmacological modulation of glucocerebrosidase activity in a transgenic mice overexpressing alpha-synuclein.

 

DROUYER Matthieu
MCCH Team, under the supervision of DESTEE Alain/TAYMANS Jean-Marc

PhD defense : 20/12/2018

Identification of protein phosphatases that act on the phosphoregulation of Leucine-Rich Repeat Kinase 2, a kinase implicated in Parkinson’s disease

 

DOMISE Manon
LB Team, under the supervision of VINGTDEUX Valérie

PhD defense : 17/12/2018

Role of AMP-activated Protein Kinase (AMPK) deregulation in Alzheimer’s disease

 

DANIS Clément
LB Team, under the supervision of LANDRIEU Isabelle/BUEE Luc
PhD defense : 14/12/2018
Characterization of single domain antibodies directed against the Tau protein

 

ALBERT Marie
LB Team, under the supervision of COLIN Morvane
PhD defense : 10/12/2018
Passive anti-Tau immunotherapy reduce Tau seeding and spreading in transgenic mouse models based on intracranial-injection of P301L-K18 fibrils or AD lysate.

 

MOPIN Alexia
BQ Team, under the supervision of BRINSTER Carine

PhD defense : 07/12/2018

Development of a syngeneic mouse model of acute myeloïd leukemia and measurable residual disease expressing or not the Wilms’ Tumor 1 gene.

 

JAMBON Samy
BQ Team, under the supervision of DAVID Marie-Hélène

PhD defense : 03/12/2018

Identification of the transcription factor HOXA9 as a therapeutic target in renal cell carcinoma and targeting with DNA-binding ligands.

 

EVRARD Caroline
LB Team, under the supervision of SERGEANT Nicolas

PhD defense : 20/11/2018

Implication of degradation systems, the Valosin-Containing Protein and new drugs on APP metabolism: fundamental and applied aspects to Alzheimer’s Disease.

 

GILLES Melissa
LB Team, under the supervision of LEFEBVRE Bruno

PhD defense : 13/11/2018

New functions of Tau proteins in RNA metabolism.

 

SAAD Chadi
IVS Team, under the supervision of BUISINE Marie-Pierre/TOUZET Hélène

PhD defense : 26/09/2018

Characterization of non-random sequencing errors, application to mosaics and heterogeneous tumors

 

BERTHE Julie
BQ Team, under the supervision of QUESNEL Bruno/ZOUITINA Sylvie

PhD defense : 07/09/2018

Role of the PD-L1 immunoregulatory protein on the metabolism of tumor cells

 

MARCEAU Alice
BQ Team, under the supervision of PREUDHOMME Claude

PhD defense : 04/07/2018

Molecular profiling of childhood acute myeloid leukemia

 

LAMBERT Mélanie
BQ Team, under the supervision of DAVID Marie-Hélène

PhD defense : 23/03/2018

Leukemogenic effects of HOXA9 transcription factor and validation of its functional inhibition by DNA ligands.

 

PELLEGRINO Giuliana
VP Team, under the supervision of SHARIF Ariane

PhD defense : 20/12/2017

Cell neogenesis in the postnatal hypothalamus as a new mechanism of control of the reproductive function.

 

CARTON Céline
BQ Team, under the supervision of IDZIOREK Thierry

PhD defense : 15/12/2017

Oncogenic role of p65 / RelA Nf-kB fragments generated by RIPK3 activity.

 

DUPLOYEZ Nicolas
BQ Team, under the supervision of PREUDHOMME Claude & CAYUELA Jean-Michel

PhD defense : 15/12/2017

Acquired genomic aberrations in acute myeloid leukemia with core binding factor involvement.

 

TARDIVEL Meryem
LB Team, under the supervision of COLIN Morvane

PhD defense : 06/12/2017

Nanotubes, a new cellular communication pathway involved in the neuron-neuron propagation of pathological Tau species.

 

MALONE Samuel Andrew
VP Team, under the supervision of GIACOBINI Paolo

PhD defense : 20/10/2017

Morphological, molecular and genetic aspects of the GnRH neuronal migratory process in mice and humans.

 

GIBAULT Floriane
PM Team, under the supervision of COTELLE Philippe

PhD defense : 13/10/2017

Design and synthesis of YAP-TEAD complex inhibitors as new anticancer drugs

 

DUROUX Romain
PM Team, under the supervision of YOUS Saïd

PhD defense : 22/09/2017

Design, synthesis and evaluation of new A2A antagonists for the treatment of neurodegenerative disease.

 

LEGHAY Coline
LB Team, under the supervision of HAMDANE Malika

PhD defense : 19/09/2017

Functional investigation of new N-terminally truncated Tau species and relevance to Alzheimer’s disease.

 

MANIEZ Salomon
BQ Team, under the supervision of ROCHE-LESTIENNE Catherine & LELEU Xavier

PhD defense : 04/07/2017

Targeting MYC in Multiple Myeloma by interfering with the LIN28B/let-7 axis and inhibiting translation initiation.

 

GAUDELOT Kelly
IVS Team, under the supervision of PERRAIS Michaël

PhD defense : 23/06/2017

Role of microRNA-21 on tumor progression and chemoresistance of renal clear cell.

 

COPPIN Lucie
IVS Team, under the supervision of PIGNY Pascal

PhD defense : 12/06/2017

Mechanisms of post-transcriptional regulation of mucins expression by galectin-3.

 

SEGAOULA Zakaria
BQ Team, under the supervision of ZOUITINA Sylvie

PhD defense : 07/04/2017

Preclinical and clinical relevance and validations of the spontaneous canine model of melanoma in therapeutic development in oncology

 

ANDRE Fanny
BQ Team, under the supervision of MARCHETTI Philippe

PhD defense : 19/01/2017

INFLUENCE OF MITOCHONDRIAL METABOLISM IN SURVIVAL AND DEATH OF TUMOR CELLS: INTEREST OF MITOCHONDRIAL TARGETING FOR CANCER TREATMENT

 

PAPEGAEY Anthony
LB Team, under the supervision of BUEE-SCHERRER Valérie

PhD defense : 19/12/2016

Biochemical and proteomic characterization of frontotemporal lobar degeneration

 

CHACHLAKI Konstantina
VP Team, under the supervision of PREVOT Vincent & GARTHWAITE John  PhD defense : 19/12/2016

Molecular characterization of NOS-synthesizing neurons and assessment of their function in the maturation of the hypothalamic axis and the acquisition of reproductive capacity

 

CHAUDERLIER Alban
LB Team, under the supervision of GALAS Marie-Christine

PhD defense : 16/12/2016

Atypical functions of Tau protein : Roles in nucleic acid protection and RNA metabolism.

 

BOYER Thomas
BQ Team, under the supervision of ROCHE Catherine

PhD defense : 15/12/2016

CD81 in acute myeloid leukemia : phenotypic, clinical and biological aspects.

 

HUIN Vincent
LB Team, under the supervision of SABLONNIERE Bernard & DHAENENS Claire-Marie

PhD defense : 15/12/2016

Epigenetics of the MAPT gene in tauopathies.

 

STIEVENARD Alicia
MCCH Team, under the supervision of MAILLIOT-VANBESIEN Christel

PhD defense : 09/12/2016

Investigation of the roles of ghrelin in experimental models of early stages of Parkinson’s disease: towards a clarification of ghrelin’s diagnostic and therapeutic potentials.

 

CORVAISIER Matthieu
IVS Team, under the supervision of HUET Guillemette

PhD defense : 29/11/2016

Involvement of the transcriptional coactivators YAP/TAZ in the regulation of the switch from tumor growth to dormancy: molecular mechanisms et therapeutical perspectives.

 

OSTYN Pauline
BQ Team, under the supervision of FORMSTECHER Pierre

PhD defense : 27/09/2016

Inflammatory factors and control of quiescence / activation of melanoma cancer stem cell.

 

POULAIN Stéphanie
BQ Team, under the supervision of PREUDHOMME Claude

PhD defense : 21/09/2016

Genomic landscape of CXCR4 mutation in Waldenstrom Macroglobulinemia.

 

VASSEUR Romain
IVS Team, under the supervision of JONCKHEERE Nicolas

PhD defense : 14/12/2015

Study of the control of mucin MUC4 by oncogen K-RAS in pancreatic cancer.

 

MARCINIAK Elodie
LB Team, under the supervision of HUMEZ SANDRINE

PhD defense : 14/12/2015

Neuroinflammation & Insulin resistance: Contribution to the pathophysiological development of Alzheimer’s disease.

 

NKILIZA  Aurore,
MCCH Team, under the supervision of DESTEE Alain

PhD defense : 11/12/2015

Transcriptome analysis of peripheral blood mononuclear cells provide insights on molecular mechanisms of Parkinson’s disease.

 

ALVES-PIRES Claire
LB Team, under the supervision of BUEE Luc & MONACA Christèle

PhD defense : 10/12/2015

Alzheimer’s disease and sleep apnea syndrome: two linked pathologies? Study of the consequences of a hypoxic stress on cognition and Tau pathology in the THY-Tau22 transgenic mouse model.

 

DESURMONT Thibault
IVS Team, under the supervision of TRUANT Stéphanie

PhD defense : 24/11/2015

Study of the implication of chemokines and their receptors in the occurrence of metastatic relapse for patients with metastatic colorectal cancer and treated by liver surgery with or without neoadjuvant chemotherapy.

 

RENAUD Florence
IVS Team, under the supervision of BUISINE Marie-Pierre

PhD defense : 16/11/2015

Toward a best understanding of serrated colorectal tumors.

 

PORET Nicolas
BQ Team, under the supervision of ZOUITINA-GALIEGUE Sylvie

PhD defense : 30/09/2015

Impact of CD38 in Hairy Cell Leukemia.

 

VANACKER Charlotte
VP Team, under the supervision of PREVOT Vincent

PhD defense : 28/09/2015

Study of the role of Neuropilin-1 receptor expression and calcium-dependent exocytosis in GnRH neuron on GnRH system development and puberty onset.

 

GAY Marion
PM Team, under the supervision of MELNYK Patricia & CARATO Pascal

PhD defense : 24/09/2015

Design, synthesis and evaluation of compounds interacting with protein degradation for the treatment of neurodegenerative diseases.

 

SPOLCOVA Andrea
LB Team, under the supervision of GALAS Marie-Christine

PhD defense : 23/09/2015

Impact of different types of antidiabetic interventions on the development of neurodegenerative changes in brains of diabetic mice and rats.

 

DUJARDIN Simon
LB Team, under the supervision of COLIN Morvane

PhD defense : 21/09/2015

From cells to primates, pathophysiological propagation of Tau proteins.

 

DERISBOURG Maxime
LB Team, under the supervision of HAMDANE Malika

PhD defense : 30/03/2015

Identification and characterization of new N-terminally truncated Tau species.

 

MOAS Valeria
PM Team, under the supervision of MELNYK Patricia

PhD defense : 05/02/2015

Design, synthesis and evaluation of new antagonist ligands of A2A rceptors.

 

DEBROUCKER Amélie
MCCH Team, under the supervision of CHARTIER-HARLIN Marie-Christine

PhD defense : 21/01/2015

Study of the p.R1205H mutation of the EIF4G1 gene identified in a familial form of Parkinson’s disease.

 

TREHOUX Solange
IVS Team, under the supervision of VAN SEUNINGEN Isabelle

PhD defense : 15/01/2015

Identification of new miRNA regulating MUC1 and determination of their functional biological roles and involvement in drug resistance of pancreatic cancer.

 

COLLDEN Gustav
VP Team, under the supervision of BOURET Sébastien

PhD defense : 26/11/2014

Metabolic Hormones in Postnatal Programming of Obesity.

 

MEQUINION Mathieu
VP Team, under the supervision of VILTART Odile

PhD defense : 30/10/2014

Peripheral and central alterations in a chronic model of food restriction : role of ghrelin.

 

CORAZAO-ROZAS Paola
BQ Team, under the supervision of KLUZA Jérôme

PhD defense : 09/10/2014

Mitochondrial oxidative metabolism can be therapeutically exploited for the treatment of metastatic melanoma.

 

LECLERCQ Julien
PM Team, under the supervision of LEBEGUE Nicolas

PhD defense : 25/09/2014

Conception, Synthèse et Evaluation Pharmacologique de Nouveaux Inhibiteurs de la Kinésine Eg5.

 

CIMINO  Irène
VP Team, under the supervision of GIACOBINI Paolo

PhD defense : 24/09/2014

Study of new molecular factors regulating GnRH migration, axonal targeting and neurosecretion: insights into the acquisition of reproductive competence.

 

LANDAGARAY Elodie
PM Team , under the supervision of YOUS Saïd

PhD defense : 21/07/2014

Design, synthesis and pharmacological evaluation of potential antidepressants: mixed ligands of melatoninergic MT1 / MT2 receptors and serotonin 5-HT2c receptors.

 

GNEMMI Viviane
IVS Team, under the supervision of AUBERT Sébastien

PhD defense : 25/05/2014

MUC1 role in renal epithelial cell plasticity.

 

LAHDAOUI Fatima
IVS Team, under the supervision of VAN SEUNINGEN Isabelle

PhD defense : 19/03/2014

Regulation of MUC4 expression by miRNAs and identification of new miRNAs in pancreatic cancer.

 

BOUILLEZ Audrey
IVS Team, under the supervision of PERRAIS Michaël

PhD defense : 14/03/2014

Involvement of the membrane-bound mucin MUC1 in renal-clear cell carcinoma progression and identification of new therapeutic targets.

 

VIOLET Marie
LB Team, under the supervision of GALAS Marie-Christine

PhD defense : 28/02/2014

Atypical functions of Tau in physiological and pathological condition.

 

VANDOMME Jérôme
BQ Team, under the supervision of POLAKOWSKA Renata

PhD defense : 13/01/2014

Study of signaling pathways controling quiescence, propagation and differenciation of dental pulp stem cells.

 

GRONNIER Caroline
IVS Team, under the supervision of MARIETTE Christophe & LETEURTRE Emmanuelle

PhD defense : 19/12/2013

Place of the operatively induced duodeno-esophageal reflux rat model in understanding the esophageal carcinogenesis. Towards the identification of early diagnostic and therapeutic tools.

 

LAURENT Cyril,
LB Team, under the supervision of BLUM David

PhD defense : 17/12/2013

Consequences of genetic and pharmacological blockade of A2A receptor in a AD-like Tau pathology transgenic mouse model. Relationship with neuro-inflammatory processes.

 

CARPENTIER Céline
LB Team, under the supervision of CAILLET Marie-Laure

PhD defense : 16/12/2013

Study of Tau alternative splicing in a model of Tauopathie : myotonic dystrophy type 1.

 

NUGUES Anne-Lucie
BQ Team, under the supervision of QUESNEL Bruno

PhD defense : 28/11/2013

Alteraction of ripoptosome in acute myeloid leukemia.

 

DONNIER-MARECHAL Marion
PM Team, under the supervision of MELNYK Patricia & CARATO Pascal

PhD defense : 26/09/2013

Conception, synthesis and evaluation of new ligands of the sigma-1 protein for neuroprotective purposes.

 

LANGLET Fanny
VP Team, under the supervision of DEHOUCK Bénédicte

PhD defense : 20/09/2013

Study on blood/metabolic hypothalamus interfaces during an energy imbalance: Median eminence plasticity and impact on the regulation of food intake.

 

JUMEAU Fanny
LB Team, under the supervision of SERGEANT Nicolas & MITCHELL Valérie

PhD defense : 16/09/2013

Human sperm proteome : a powerful tool to understand and characterize sperm quality.

 

GUERRESCHI Pierre
BQ Team, under the supervision of MARCHETTI Philippe

PhD defense : 11/09/2013

Place of murine models in the comprehension and adaptation of therapeutic care management for metastatic melanoma.

 

NHILI Raja
BQ Team, under the supervision of DAVID-CORDONNIER Marie-Hélène

PhD defense : 26/03/2013

New Therapeutic Approaches to Acute Myeloid Leukemia: Molecular and Cellular Validation of Targeting of Leukemogenic Hox Proteins.